Journal of the American Chemical Society, Vol.130, No.7, 2122-2122, 2008
Synthesis, characterization, and application of lodoacetamide derivatives utilized for the ALiPHAT strategy
Hydrophobic tags, derived from iodoacetamide, were synthesized, characterized, and utilized to alkylate peptide E-76, a known inhibitor of coagulation factor Mile, and two other cysteine containing peptides. The electrospray response of each tagged peptide was compared against the same peptide alkylated with iodoacetamide. E-76 peptide alkylated with the synthesized tags demonstrated an increase in electrospray response of up to 429 times when compared to that alkylated with iodoacetamide.