Journal of the American Chemical Society, Vol.130, No.11, 3268-3268, 2008
Direct benzylic alkylation via Ni-catalyzed selective benzylic sp(3) C-O activation
This article demonstrates the first cross coupling of benzyl ether with Grignard reagents via Ni-catalyzed benzylic sp(3) C-O activation with high efficiency and excellent chemoselectivity. Benzylic sp(3) C-O and aryl sp(2) C-O were differentiated, controlled by ligands.