Over the past few years, the discrete element method (DEM) has been used in models for the simulation of granular flows in various mixing applications. If these models have shown rather efficient, they have so far been applied to predict the behavior of small numbers of particles over limited spans of time. The objective of this work is to show that DEM-based models can be used to predict the flow behavior of large numbers of particles over large spans of time and, more particularly, mixing phenomena that take time to manifest in such systems. To this end, several large-scale DEM-based numerical investigations of the flow of monodisperse and bidisperse blends of up to 225 000 particles over a span of 120 s in a V-blender will be discussed using entities such as the particle velocity and granular temperature, the torque of the mixing system, RSD curves and mixing times. (c) 2006 Elsevier B.V. All rights reserved.