A novel magnetic microspherical catalyst support with enough mechanical strength was prepared through coating Al2O3 on a magnetic core of NiFe2O4 spinel ferrite using the oil drop method to synthesize magnetic Pd-supported catalyst for acetylene hydrogenation reaction. The synthesized core-shell composite Pd/Al2O3 catalyst shows high surface area and pore volume as well as sufficient saturated magnetization property, characterized by powder X-ray diffraction, low-temperature N-2 adsorption-desorption analysis, and magnetic measurements. Catalytic performance of this magnetic Pd/Al2O3 catalyst was measured for acetylene hydrogenation reaction in a magnetically stabilized bed (MSB) reactor under different operation conditions. Under the optimal conditions of 353 K, 1.5 MPa and a gas hourly space velocity of 12,000 h(-1), C2H2 conversion and C2H4 selectivity approximated 100% and 84%, respectively, over this magnetic Pd/Al2O3 catalyst in the MSB reactor, as a control over the commercial catalyst for hydrogenation reaction C2H2 conversion and C2H4 selectivity was. near 37 and 64% under the similar conditions. Significant improvement of acetylene hydrogenation processes over this novel magnetic catalyst enlightens us a promising route to explore process intensification techniques through MSB.