Dynamic Imaging of functionalized multi-walled carbon nanotube systemic circulation and urinary excretion

Lacerda L; Soundararajan A; Singh R; Pastorin G; Al-Jamal KT; Turton J; Frederik P; Herrero MA; Bao SLA; Emfietzoglou D; Mather S; Phillips WT; Prato M; Bianco A; Goins B; Kostarelos K

Advanced Materials, Vol.20, No.2, 225-225, 2008

DOI10.1002/adma.200702334 Export Citation

Dynamic Imaging of functionalized multi-walled carbon nanotube systemic circulation and urinary excretion

Lacerda L, Soundararajan A, Singh R, Pastorin G, Al-Jamal KT, Turton J, Frederik P, Herrero MA, Bao SLA, Emfietzoglou D, Mather S, Phillips WT, Prato M, Bianco A, Goins B, Kostarelos K

Intravenously administered multi-walled carbon nanotubes, functionalized with DTPA and radiolabeled with Indium-111, were dynamically tracked in vivo using a microSingle Photon Emission Tomography scanner. Imaging showed that nanotubes enter the systemic blood circulation and within 5 min begin to permeate through the renal glomerular filtration system into the bladder.