The equation of state derived by Hall and co-workers from the generalized Flory-dimer (GF-D) theory has been applied to real fluid calculations in this study. For each pure fluid, there are three parameters in the equation of state that are obtained from regression of saturated properties. Over one hundred pure nonpolar and polar fluids and thirteen polymeric fluids are examined in this work. The pure component parameters of these fluids show regular correlations with their characteristic properties such as the carbon number of molecular weight. Saturated vapor pressures and liquid densities of pure fluids from low molecular weight hydrocarbons to polymers are satisfactorily computed from this equation of state. This equation has also been compared with other engineering equations of state. The GF-D equation shows good correlations of pure component parameters, as well as superior accuracy to other commonly used equations.