The microporous layer (MPL) between the carbon cloth and catalyst layer is a significant part in a proton-exchange membrane fuel cell (PEMFC). The water management of membrane electrode assembly (MEA) is a crucial technology for improving performance. It is now the aim of this study to present the effects of various hydrophobic agents on the performance in a PEMFC. MPL loading with FEP121A and LDW-40 provide optimization of the performance (1007.7 and 980.33 mA/cm(2) at 0.5 V). The polarization curves of the fuel cell were plotted under similar operating conditions with different MPL. These results provided a wide and cheap choice of hydrophobic agents in the MEA.