Environmental quality has become increasingly affected by the built environment-as ultimately, buildings are responsible for the bulk of energy consumption and resultant atmospheric emissions in many countries. In recognizing this trend, research into building energy-efficiency has focused mainly on the energy required for a building's ongoing use, while the energy "embodied" in its production is often overlooked. Such an approach has led in recent years to strategies which improve a building's thermal performance, but which rely on high embodied-energy (EE) materials and products. Although assessment methods and databases have developed in recent years, the actual EE intensity for a given material may be highly dependent on local technologies and transportation distances. The objective of this study is to identify building materials which may optimize a building's energy requirements over its entire life cycle, by analyzing both embodied and operational energy consumption in a climatically responsive building in the Negev desert region of southern Israel-comparing its actual material composition with a number of possible alternatives. It was found that the embodied energy of the building accounts for some 60% of the overall life-cycle energy consumption, which could be reduced significantly by using "alternative" wall infill materials. The cumulative energy saved over a 50-year life cycle by this material substitution is on the order of 20%. While the studied wall systems (mass, insulation and finish materials) represent a significant portion of the initial EE of the building, the concrete structure (columns, beams, floor and ceiling slabs) on average constitutes about 50% of the building's pre-use phase energy. (C) 2007 Elsevier B.V. All rights reserved.