Direct epoxidation of propene with hydrogen peroxide vapor was conducted in a microstructured reactor containing TS-1 catalyst coatings. At 140 degrees C, 1 bar, 5 vol % hydrogen peroxide, and 15 vol % propene, productivities of more than I kg of propene. oxide per kg of catalyst and hour are obtained in lab scale, which is in an industrially highly relevant range. Excellent selectivities to propene oxide based on propene of > 90% were reached. Potential and need for improvement lie in the propylene oxide selectivity based on hydrogen peroxide, which was observed to be about 25%. By increasing the molar excess of propene to about 6.6, propylene oxide selectivities related to hydrogen peroxide of up to 60% have been observed in the pilot plant.