Results from a theoretical study of the interactions of a OH radical on (H2O)(20), (H2O)(24), and (H2O)(28) clusters used as a novel model of a water droplet are presented. This work shows that there is competition between OH radicals trapped on the surface and those encapsulated inside of a water, cage. This is contrary to previous findings of HO2 radical interactions with water clusters. Natural bond orbital (NBO) analysis is used to analyze the bonding feature of OH to help explain the difference in behavior between OH and HO2 radicals toward a water surface.