Preparation and Characterization of Water-Dispersible Silver Nanoparticles Stabilized by PEO-Conjugated Pro-Drugs

Tae Hwan Kim; Keunsuk Kim; Geon Hee Park; Jin Hee Choi; Sangmi Lee; Ho-Jung Kang; Jae Yeol Lee; Jungahn Kim

Macromolecular Research, Vol.17, No.10, 770-775, October, 2009

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Preparation and Characterization of Water-Dispersible Silver Nanoparticles Stabilized by PEO-Conjugated Pro-Drugs

Tae Hwan Kim, Keunsuk Kim, Geon Hee Park, Jin Hee Choi, Sangmi Lee, Ho-Jung Kang, Jae Yeol Lee, and Jungahn Kim^†

Department of Chemistry, Kyunghee University, Seoul 130-701, Korea

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ω-Anhydride-functionalized poly(ethylene oxide) (PEO) obtained from chain-end functionalization and anionic ring-opening polymerization of ethylene oxide using n-butyllithium with potassium t-butoxide in the presence of dimethylsulfoxide (DMSO) was found to be an efficient material for the preparation of water-soluble, polymeric pro-drugs. The reaction of ω-anhydride-functionalized PEO with sulfonamide or with vancomycin provided an efficient method to produce corresponding, water-soluble, PEO-conjugated sulfonamide or PEO-conjugated, vancomycin pro-drugs. These were used successfully to prepare water-dispersible, silver nanoparticles. In this study, the particle sizes were in the range of 5~40 nm. The resulting products were characterized by 1H NMR spectroscopy, transmission electron microscopy, electron and X-ray diffraction, size exclusion chromatography, and UV/Visible spectroscopy.

Keywords:water-dispersible Ag nanoparticle;PEO-conjugated pro-drugs;PEO-sulfadiazine

[References]

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[2] Wiley B, Sun Y, Chen J, Cang H, Li ZY, Li X, Xia Y, Mater. Res. Soc. Bull., 30, 356 (2005)

[3] Sun Y, Xia Y, Science, 298, 2176 (2002)

[4] Wang J, Liu GD, Merkoci A, J. Am. Chem. Soc., 125(11), 3214 (2003)

[5] Bau R, Zhang J, Beckman EJ, Virji M, Pasculle WA, Wells A, Biomaterials, 27, 4304 (2006)

[6] Panacek A, Kvitek L, Prucek R, Kolar M, Vecerova R, Pizurova N, Sharma VK, Nevecna T, Zboril R, J. Phys. Chem. B, 110(33), 16248 (2006)

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[8] Lu L, Kobayashi A, Tawa K, Ozaki Y, Chem. Mater., 18, 4894 (2006)

[9] Zou XQ, Dong SJ, J. Phys. Chem. B, 110(43), 21545 (2006)

[10] Shevchenko EV, Talapin DV, Schnablegger H, Kornowski A, Festin O, Svedlindh P, Haase M, Weller H, J. Am. Chem. Soc., 125(30), 9090 (2003)

[11] Narayanan R, El-Sayed MA, J. Am. Chem. Soc., 125(27), 8340 (2003)

[12] Wiley BJ, Im SH, Li ZY, McLellan J, Siekkinen A, Xia YA, J. Phys. Chem. B, 110(32), 15666 (2006)

[13] Wiley BJ, Sun Y, Mayers B, Xia Y, Chem. Eur. J., 11, 454 (2005)

[14] Gupta A, Silver S, Nature Biotechnol., 16, 888 (1998)

[15] Morones JR, Elechiguerra JL, Camacho A, Holt K, Kouri JB, Ramirez JT, Yacaman MJ, Nanotechnology, 16, 2346 (2005)

[16] Moskovits M, Suh JS, J. Am. Chem. Soc., 107, 6826 (1985)

[17] Cheung RP, DiPiro JT, Pharmacotherapy, 6, 153 (1986)

[18] Ringsdorf H, J. Polym. Sci. Symp., 51, 135 (1975)

[19] Supuran CT, Casini A, Scozzafava A, Med. Res. Rev., 23, 535 (2003)

[20] Morton M, Fetters LJ, Rubber Chem. Technol., 48, 359 (1975)

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[22] Gilman H, Cartledge FK, J. Organomet. Chem., 2, 447 (1964)

[23] Kwark YJ, Kim J, Novak BM, Macromol. Res., 15(1), 31 (2007)

[24] Harris JM, Chess RB, Nature Rev. Drug Dis., 2, 214 (2003)

[25] Wiley B, Sun Y, Mayers B, Xia Y, Chem. Eur. J., 11, 454 (2005)

[26] Sands DE, Introduction to Crystallography, Dover, New York, 1993, p 51

[27] Lisowski MS, Liu Q, Cho JD, Runt J, Yeh FJ, Hsiao BS, Macromolecules, 33(13), 4842 (2000)

[28] Panigrahi S, Praharaj S, Basu S, Ghosh SK, Jana S, Pande S, Vo-Dinh T, Jiang H, Pal T, J. Phys. Chem. B, 110(27), 13436 (2006)

[29] He S, Yao J, Xie S, Gao H, Pang S, J. Phys. D: Appl. Phys., 34, 3425 (2001)

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[31] Xia H, Zhang Y, Sun S, Fang Y, Colloid Polym. Sci., 285, 1655 (2007)