A novel approach for the synthesis of ethyl lactate using a simulated moving bed reactor was evaluated by experiments as well as by simulations. A mathematical model considering external and internal mass-transfer resistances and variable velocity due to change of liquid composition was developed to describe the dynamic behaviour of the SMBR and it was validated by the experiments performed; it was observed that the experimental results were well predicted by the model. The effect of operating parameters, as the feed composition, SMBR configuration and switching time on the SMBR performance parameters at the optimal operating points and/or reactive/separation regions was studied. It was shown that the SMBR is a very attractive technology for the production of ethyl lactate, since under appropriate conditions the lactic acid conversion can be driven to completion and productivity as high as 32 Kg(EL)/(L-ads day) and purity of 95% can be obtained. (C) 2009 Elsevier Ltd. All rights reserved.