Mussels secrete specialized adhesives known as mussel adhesive proteins, which allow attachment of the organisms to underwater marine environments. Obtaining large quantities of naturally derived mussel adhesive proteins adhesives has proven to date rather problematic, thus, synthetic analogs of mussel adhesive proteins have recently been developed. We report deposition of 1: 100 and 1: 1000 poly[(3,4-dihydroxystyrene)-co-styrene)] mussel adhesive protein analogs by matrix assisted pulsed laser evaporation ( MAPLE) using an ArF* excimer laser source. The deposited films have been evaluated for their antifouling behavior. The MAPLE-deposited synthetic mussel adhesive protein analog thin films are homogenous and adhesive, making the use of these materials in thin film form a viable option. (C) 2008 Elsevier B. V. All rights reserved.