This paper presents an overview of the current status of measurement methodology for the purpose of determining multiple metals stack emissions of up to sixteen metals using one sampling train developed by the Atmospheric Research and Exposure Assessment Laboratory of the United States Environmental Protection Agency (US EPA). In the methodology isokinetic sampling from a grid of points produces a representative sample from which the multiple metal emissions can be measured in the sample from one train. Metals in the stack particulate matter are measured separately from those in the stack gases. The samples are prepared by digestion for subsequent analysis by inductivity coupled plasma or atomic absorption spectroscopy. The train was developed for measuring the following sixteen metals: total Cr, Cd, As, Ni, Mn, Be, Cu, Zn, Pb, Se, P, Tl, Ag, Sb, Ba, and Hg. Emission factor development, research requiring measurement of metals emissions, and determining emission compliance are important potential applications of this type of methodology.