This work presents a numerical study of the hydrodynamic of spouted beds using computational fluid dynamics (CFD) simulation. Scaling relationships proposed by He et al. [He et al., Chem. Eng. Sci. 1997;52:329-339] for spouted bed systems based on similitude method are numerically investigated using CFD simulation. In the present work it is verified that the spouted bed scale-up relationships of He et al. [He et al., Chem. Eng. Sci. 1997;52:329-339] produce good numerical results when all of the scale-up relationships are satisfied. It is also verified the behaviour of the numerical results when the scaling procedure is applied in a practical condition. In this case, the properties of fluid and solid are kept constant, which is a real situation of a scale-up procedure in a spouted bed used for drying of grains. In this work it is possible to verify that CFD simulation is a useful tool to evaluate similitude methods in spouted bed (multiphase flow) systems. The commercial package FLUENT 6.3.26 was used in all simulations.