The scope of metal loaded gamma-Al2O3 materials as catalysts in the ozone initiated functionalisation of higher n-alkanes is investigated at moderate conditions (20 +/- 1 C and similar to 1 atm). In the ozone initiated oxidation of the higher hydrocarbon, n-hexadecane with 0.5% Pd or Ni or V loaded gamma-Al2O3 catalysts lead to the keto-isomers as main products, and organic acids as minor products. This paper emphasises the effect of gamma-Al2O3 catalysts on the conversion, selectivity and reaction products during ozonation of n-hexadecane.