The presence of sulphur containing compounds, naturally occurring in natural gas or added as odorants, can adversely affect the performance of noble metals based catalysts for the partial oxidation of methane to syngas. In this paper the effect of SO2 addition on the catalytic partial oxidation of methane was investigated on Rh (1 wt.%) catalysts prepared by incipient wetness impregnation method on two different commercially available high temperature gamma-alumina supports stabilized either with 10% SiO2 or 3% La2O3. Based on the results of catalytic activity measurements and in-situ FT-IR spectroscopic characterisation, as well as TPR/TPD studies, it has been shown that the presence of sulphur can severely suppress the formation of synthesis gas by inhibiting the reforming reactions during the catalytic partial oxidation of methane. The results also demonstrated that the support plays a crucial role in the partial oxidation reaction. In the presence of a sulphating support such as La2O3-Al2O3 the partial oxidation reaction was much less inhibited than a less sulphating support such as SiO2-Al2O3. The sulphating support acts as a sulphur storage reservoir, which minimises the poison from adsorbing on or near the active Rh sites where reactions take place.