Three-component hybrid catalyst comprised of Co/SiO2, Pd/beta-zeolite and CuO/ZnO/Al2O3 with different configurations was applied for the effective production of gasoline-range iso-paraffins from synthesis gas. In the case of the powdery mixture, a killing effect of CuO/ZnO/Al2O3 on Co/SiO2 for the Fischer-Tropsch reaction was observed. On the contrary, individual functions of the above-mentioned components were successfully achieved when the hybrid catalyst with the same composition was prepared in a granular form. The reason is tentatively explained as the feasibility for the interfacial migration of the zinc component from CuO/ZnO/Al2O3 to Co/SiO2.