A kinetic model developed to describe flotation in a bubble column is presented. This model, developed on the basis of the theory of mass transfer in gas-liquid flows, makes explicit in its formulation the effect of the superficial saturation of bubbles on the kinetics of flotation. The model is applied to the simulation of flotation column experiments for which the classical first-order models, commonly used in flotation modeling, are insufficient to represent the flotation kinetics. The results of the simulations obtained under different hypotheses of simplification and compared to experimental data show that the model succeeds in representing the flotation kinetics in these cases.