This study aims to develop a general model that is able to describe powder flow and mixing in static mixers, regardless of the type of mixer or the mixing configurations. The process model is based oil a homogeneous Markov chain describing the flow of each component through the mixing zone by a series of interconnected cells. It accounts for the number of mixing elements and their disposition in the mixer. as well as particle segregation via different transition probabilities. Some simulations are given to emphasize this particular aspect. Other outcomes of the model include the number of passages to reach a required mixture quality. as well as the asymptotic distribution of components. A laboratory static mixer of revolving type was designed specially for this study. It comprises up to 10 mixing sections, and its high internal voidage favours free flow of the powder. Segregating and non-segregating mixtures have been used to test the model and adjust unknown parameters. The model gives very satisfying results. In particular, it is able to account for the oscillating character of mixing kinetics due to particle segregation. It is also suggested that these parameters could be linked separately to powder flowability and mixing element characterization. (c) 2008 Elsevier B.V. All rights reserved.