An overall three-step six-component chemical kinetics model which includes CH4 + O-2 -> CO + H2O + H-2 and reversible 2CO + O-2 <-> 2CO(2) and CH4 + H2O <-> CO +3H(2) reactions is elaborated for the simulation of partial oxidation of methane in inert porous media. Procedure of the model adjusting to the experimental data is described. Kinetic parameters of the model are derived on the basis of temperature-flow rate, H-2 and CO output concentration-flow rate and temperature-pressure experimental correlations. It is fond that extremely slow solid body temperature growth with flow rate T-s,T-max(G) reported in the works on partial oxidation of methane (and other hydrocarbons) in inert porous media may be reproduced by the model. The model is designed for optimization, scale up and design assistance of the reactors of partial oxidation of methane. It is demonstrated that the overall chemical kinetics model can be combined with detailed gas-phase kinetics model for the investigation of detailed composition of syngas and intermediary components. (C) 2008 Elsevier B.V. All rights reserved.