Mass transfer between matrix and fracture is encountered during enhanced oil recovery applications, greenhouse gas sequestration and contaminant transportation in naturally fractured Subsurface reservoirs. We used a combination of laboratory scale physical experiments and numerical simulations to evaluate the mass transfer between fracture and matrix and effective diffusion/dispersion in the matrix Of naturally fractured subsurface reservoirs. Experiments on artificially fractured porous media showed the influence of various factors such as injection flow rate, matrix-fracture length, solute viscosity and density and matrix porosity/permeability on solvent/solute diffusion into/from the porous matrix media from/into the adjacent fracture. Mass transfer between matrix and fracture was simulated using advection-convection equation governing the system. Experimental results were compared with the results from numerical simulations to evaluate the major contributing Parameters, mass transfer rate and effective matrix diffusion coefficient. It was found that effective matrix diffusion coefficient in the matrix is higher than the mutual diffusion coefficient. The mass transfer rate was found to be linearly dependent on velocity and affected by wettability as well as rock properties. These two parameters are correlated with other factors governing the physical process. These correlations would be useful in modeling mass transfer into matrix during solvent flow in fracture. (C) 2008 Elsevier B.V. All rights reserved.