This work presents a general methodology to determine kinetic models of solid thermal decomposition with thermogravimetric analysis (TGA) instruments. The goal is to determine a simple and robust kinetic model for a given solid with the minimum of TGA experiments. From this last point of view, this work can be seen as an attempt to find the optimal design of TGA experiments for kinetic modelling. Two computation tools were developed. The first is a nonlinear parameter estimation procedure for identifying parameters in nonlinear dynamical models. The second tool computes the thermogravimetric experiment (here, the programmed temperature profile applied to the thermobalance) required in order to identify the best kinetic parameters, i.e. parameters with a higher statistical reliability. The combination of the two tools can be integrated in an iterative approach generally called sequential strategy. The application concerns the thermal degradation of cardboard in a Setaram TGA instrument and the results that are presented demonstrate the improvements in the kinetic parameter estimation process. (C) 2008 The Institution of Chemical Engineers. Published by Elsevier B.V All rights reserved.