Chemical Physics Letters, Vol.458, No.4-6, 359-362, 2008
Kinetic oscillations in the expression of messenger RNA, regulatory protein, and nonprotein coding RNA
The interplay of messenger RNA (mRNA), protein, produced via translation of this RNA, and nonprotein coding RNA (ncRNA) may include regulation of the ncRNA production by protein and (i) ncRNA-mRNA association or (ii) ncRNA-protein association resulting in degradation of the corresponding complex. The kinetic models, describing these two scenarios and taking into account that the association of ncRNA with a target occurs after ncRNA conversion from the initial form to the final form (e. g., from a long RNA to microRNA), are found to predict oscillations provided that the rate of ncRNA formation increases with increasing protein population. (c) 2008 Elsevier B.V. All rights reserved.