The global kinetic models of methanol synthesis from carbon monoxide, carbon dioxide and hydrogen are investigated in the three-phase well mixed reactor with mechanical agitator under such conditions: pressure 5 MPa, temperature 210 approximately 250-degrees-C, synthesis catalyst C301, medicinal grade liquid paraffin as inert medium, rotation speed of agitator 950 rpm. By the improved Gauss-Newton method, the global kinetic models are developed.