Solid-state luminescence quantum efficiency is modulated drastically by CH-O interaction and packing rigidity of secondary ammonium anthracene-2,6-disulfonate. Appropriate alkyl chains of amines gave small free space and long CH-O distance, resulting in strong luminescence due to suppression of nonradiative decay. This is the first demonstration that CH-O intermolecular interaction has great influence on solid-state luminescence quantum efficiency.