Chemistry Letters, Vol.38, No.6, 524-525, 2009
Expeditious Construction of Quinazolines via Bronsted Acid-induced C-H Activation: Further Extension of "tert-Amino Effect"
A simple method for the synthesis of quinazolines was developed by exploiting the "tert-amino effect." A catalytic amount of Bronsted acid (TsOH center dot H2O) worked as an effective activator for the concise construction of a quinazoline framework from o-formylaniline and amine.