Using pressure swing adsorption (PSA) technology to purify carbon monoxide (CO) discharged from industrial gases is a high-efficiency and economical method. In this article, a four-bed PSA experiment for CO purification was improved and optimized, in which a set of 120 m(3).h(-1) pilot-scale PSA device was developed to purify CO from industrial tail gases, a set of control systems suitable for industry production was developed, and the influences of the operating parameters on CO purification were investigated. The experimental results indicated that the pilot-scale PSA device could produce qualified product gas and get high CO recovery ratio under optimized conditions. The research may provide reliable fundamental data, for industrial scale utilization of CO, from industrial tail gases, and have strong market competitive power and a broad promoted application prospect.