The monitoring results of two "REMOS" telemetric stations, in River Nestos, are compared. The first one is situated at the Nestos Delta, near Hrisoupoli (Remote Station - RS "Nestos"), and the second one is situated at the course of Nestos, near the Greek-Bulgarian borders (Remote Station - RS "Pagoneri"). The fluctuations of the qualitative and quantitative water parameters have been normalized in the Nestos Delta, following its new anthropogenic regime, whereas at the course of the river, above the power plants, important peaks are noted in the qualitative and quantitative parameters. During the statistical process of these parameters, their trend is examined and their goodness-of-fit assessment of the normal and log-normal distribution is checked, for a significance level of 5%. From the parameters that were examined for RS "Nestos", the water level (H) and the water electrical conductivity (ECw) presented a trend, while for RS "Pagoneri", the same parameters did, including dissolved oxygen (DO). A linear regression model was best fitted at all of these parameters. During the goodness-of-fit test, for RS "Nestos" it was reported that water level (H) and water temperature (T-w) follow the normal distribution (the first marginally), while air temperature (T-a) follows the log-normal distribution. On the other hand, in RS "Pagoneri", none of the parameters follow a distribution.