A system for removal of Cu2+ from aqueous solution by foam fractionation is proposed. The effects of pH, gas flow rate, surfactant concentration and froth/solution ratio on the removal rate and the enrichment ratio were studied to optimize the conditions. The results show that the removal rate increased with gas flow rate decreased, surfactant concentration increased and the froth/solution ratio increased, and was higher at pH4.0-5.0 than at other pH value. The optimum separation conditions were pH5.0, 200 mL/min of gas flow rate, 0.15 g/L of surfactant concentration and 1.1 of froth/solution ratio. Under the optimum conditions, the removal rate was 97.2% and the enrichment was 53.0. (C) 2009 Elsevier B.V. All rights reserved.