The methanol electrooxidation reaction was studied on carbon-dispersed Pt-rare earth oxide nanocatalysts with RuO2 nanorod in H2SO4/CH3OH solutions. Transmission electron microscopy (TEM) and X-ray diffraction (XRD) were used to characterize PtRuO2-Ce0.5Pr0.50O2-delta/C catalysts. The electrochemical activities for the methanol electrooxidation reaction were measured in a powder microelectrode by cyclic voltarnmetry. The results showed that PtRuO2-Ce0.5Pr0.5O2-delta/C exhibited the highest electroactivity and PtRuO2-Pr6O11/C exhibited extremely small current density. Interpretation of trial results was based on the fact that, in contrast to PtRu/C catalysts, PtRuO2-Pr6O11/C catalysts had better ability to dehydrogenate methanol and enhance the effect of the bifunctional mechanism in the methanol oxidation reaction.