Supercritical carbon dioxide has been considered an appropriate alternative for extraction and purification process of cosmetics, pharmaceuticals, food Supplements and natural products. Solubility information of biological compounds is essential for choosing supercritical fluid (SCF) processes. The Solubility of iodopropynyl butylcarbamate (IPBC), a fungicide and anti-dandruff agent, was measured in supercritical carbon dioxide with a high pressure apparatus equipped with a variable Volume view cell at 313.15, 323.15, and 333.15 K and at pressure between 80 and 35 MPa. The experimental data were correlated well with Peng-Robinson equation of state (PR EOS) and quasi-chemical nonrandom lattice fluid model. (C) 2008 Elsevier B.V. All rights reserved.