The influence of different binders (alumina, silica sol, and montmorillonite) on the structure and performance of PtSnNa/ZSM-5 catalysts for propane dehydrogenation to propene was studied. Temperature-programmed desoption of ammonia (NH3-TPD), hydrogen chemisorption, BET surface area measurement, solid-state 27 A] MAS NMR spectroscopy, catalyst particle mechanical strength, and X-ray diffraction (XRD) were used to characterize the catalysts. After agglomeration with different binders, the mechanical strength of all catalyst particles increased obviously in comparison with the nonagglomerated sample and the Al species amounts of the catalysts were affected greatly by the binder. A slightly acidic change was observed for the catalysts with different binders, but the metal dispersion on the carrier of different samples was clearly different. The result of propane dehydrogenation indicated that the catalyst based on PtSnNa/ZSM-5 agglomerated with alumina showed the highest conversion and high selectivity.