A two-dimensional model for a mesh contactor utilized for acetone stripping from binary mixtures acetone-isopropanol with nitrogen as inert gas, as well as for asymmetric transfer hydrogenation of acetophenone with isopropanol as the hydrogen donor in the presence of a homogeneous catalyst and simultaneous acetone removal by stripping has been formulated and solved. Experiments have been performed with a microstructured mesh contactor that consists of parallel metal plates, gaskets, and a microstructured mesh so that passages for gas and liquid phases are formed. The model gives good agreement with experimental data for both acetone removal from a binary mixture and asymmetric transfer of hydrogenation. Theoretical and experimental investigations show that the amount of acetone removed from the liquid phase is strongly dependent on the ratio of inlet gas to liquid flowrate. For a higher ratio, more efficient acetone removal from the liquid phase is achieved. If dry nitrogen is used as a stripping agent, simultaneous evaporation of acetone and isopropanol results in significant solvent depletion of the liquid phase. In this case, the gas phase becomes saturated with solvent (isopropanol) near the reactor entrance. Due to efficient removal of acetone produced as byproduct during the reaction, reaction time in the mesh reactor can be significantly decreased as compared to a laboratory batch reactor.