Cotton and cotton/polyester fabrics containing halamine structures were able to react with certain organophosphorus pesticides upon contact. The reaction occurred at thione group in methyl parathion and malathion, and reaction products were oxon compounds. The fabric containing imide and amide halamine structures were able to oxidize 90% of methyl parathion in less than 2 h of contact time under room temperature, while the amine halamine structure needed longer time to reach the same level of oxidation. The reaction was endothermic, and the oxidation rate was in first order to the concentrations of the pesticides.