In this work, the spreading and evaporation of 2-70 pL droplet (17-50 mu m diameter) of water and ethylene glycol jetted by drop-on-demand piezo-driven jetting head on the heated substrate are studied. According to the experimental results, the interfacial oscillation phenomena of water droplet whose Ohnesorge number (Oh) is about 10(-2) is Similar to that in inviscid impact driven region, while that of ethylene glycol droplet (Oh approximate to 10(-1)) is similar to that in highly viscous impact driven region followed by capillary driven extra spreading. In addition, various time scales used for nano/micro-liter droplets agree well with the times for interfacial oscillation, viscous damping, extra wetting, and evaporation in pico-liter droplets. In the case of water droplet, the spreading processes end before the evaporation becomes significant. However, in the case of highly viscous ethylene glycol droplet, the extra wetting overlaps the evaporation at high temperature. (c) 2008 Elsevier Ltd. All rights reserved