Recent interest in electricity production using microbial fuel cells makes it important to better understand O-2 reduction in neutral solutions with non-precious metal catalysts. Higher O-2 reduction activity was obtained using iron phthalocyanine supported on Ketjen black carbon (FePc-KJB) than with a platinum catalyst in neutral pH. At low overpotentials, a Tafel slope close to -0.06 V/dec in both acid and neutral pH suggested that the mechanism of O-2 reduction on FePc is not changed with the change of pH, and the reaction is mainly controlled by Fe-II/Fe-III redox couple. This behaviour gives us new insight into catalysis using FePc, and further supports the use of FePc as a promising catalyst for the oxygen reduction applications in neutral media.