A model based on the combination of Hansen solubility parameter theory and Flory-Rehner polymer solution theory was used to determine the solubility parameters of butyl glove material provided by several different manufacturers using a nonlinear least-square regression. To evaluate the validity of this model, weight gain data were collected for 26 solvents versus butyl gloves from four different vendors. Good correlation was found with R-2 ranging from 0.858 to 0.961, which was attributed to extended weight gain testing and weight gain calculations based on glove sample weight after immersion and postdrying. Steady-state permeation rates (molar steady-state permeation rates), breakthrough times, and lag times for the butyl glove samples against solvents were determined and correlated to solvent-polymer interactive term chi phi(2)(p). A high level of correlation was observed for all glove materials. Correlation was also made with permeation data collected from three of the four glove materials, and a high degree of correlation was found with R-2 ranging from 0.8644 to 0.9369 for steady-state permeation rates (molar steady-state permeation rates), breakthrough times, and lag times. (C) 2008 Wiley Periodicals, Inc.