Amino-terminated anionic aqueous-based polyurethane (PU) dispersion was obtained from NCO-terminated PU prepolymer, which was neutralized with an excess triethylamine (TEA) and chain extended by ethylene-diamine (EDA) during water dispersion process. That PU prepolymer was obtained from a polyaddition reaction of isophorone diisocyanate (IPDI), polypropylene glycol-2000 (PPG-2000), and 2,2'-dimethyol propanoic acid (DMPA). This aqueous-based PU dispersion was treated with trimethylolpropane triglycidyl ether (TMPTGE) as a latent curing agent and resulted in a self-cured PU resin on drying. A model ring-opening curing reaction between oxirane group of TMPTGE with thermal amino group of PU was demonstrated by glycidol with eta-butyl amine. The physical and mechanical properties as well as thermogravimetric analyses of these self-cured PU resins were evaluated in this article. (C) 2008 Wiley Periodicals, Inc. J Appl Polym Sci 110:725-731, 2008.