Journal of Bioscience and Bioengineering, Vol.106, No.1, 99-102, 2008
In vivo protein delivery to human liver-derived cells using hepatitis B virus envelope pre-S region
Human hepatocyte-specific delivery of green fluorescent protein was succeeded in the mouse xenograft model by fusion with hepatitis B virus surface antigen pre-S regions (pre-S(1+2)), not with each pre-S region. The entire pre-S region would be useful for human liver-specific delivery of therapeutic proteins and bio-imaging fluoroproteins in biomedical field.