The supercritical technology has been considered as an appropriate alternative for separation of biomaterials from cosmetic, food, and pharmaceutical products. The solid solubility of biological compounds is the most important thermodynamic parameter in the supercritical extraction and purification. The equilibrium solubility of two biocides, climbazole, and triclocarban was measured in supercritical carbon dioxide with static method in the pressure range from (10 to 40) MPa and at temperatures equal to (313.2, 323.2, and 333.2) K. The experimental data were correlated by Peng-Robinson equation of state and quasi-chemical nonrandom lattice fluid model. (C) 2008 Elsevier Ltd. All rights reserved.