Thiazolidinedione (TZD) derivatives have been found to possess potent immunostimulatory properties as well as antiarthritic, antidiabetic and oncostatic activities. These compounds are free radical scavengers. Photophysical properties of the compounds have been Studied in different aqueous micellar environments using steady state and time resolved emission spectroscopy. Appreciable hypsochromic shifts with enhancement in tire fluorescence intensities have been observed in the ionic micellar media. The binding constants and energy changes doting probe-micelle binding have been evaluated from relevant fluorescence data. Polarity of the microenvironment surrounding the probe molecules has been determined in the micellar systems. (C) 2008 Elsevier Inc. All rights reserved.