The uptake and persistence behaviour of the insecticide imidacloprid in tomato plants treated by (i) foliar spray application and (ii) soil irrigation was studied using two plant uptake models. In addition to a pesticide deposition model, a dynamic root uptake and translocation model was developed, and both models predict residual concentrations of pesticides in or oil fruits. The model results were experimentally validated. The fraction of imidacloprid ingested by the human population is on average 10(-2) to 10(-6). depending oil the time between pesticide application and ingestion, the processing step. and the application method. Model and experimentally derived intake fractions deviated by less than a factor of 2 for both application techniques. Total imidacloprid residues were up to five times higher in plants treated by foliar spray application than by soil irrigation. However, peeling tomatoes treated by spray application reduces the human intake fraction by up to three orders of magnitude. Model calculations Suggest that drip-irrigation in a closed hydroponic system minimizes worker and consumer exposure to pesticides and prevents runoff of pesticide by spray drift and leaching into the environment. (C) 2008 Elsevier B.V. All rights reserved.