Spark Plasma sintering (SPS) technique allows powders to be compacted at low temperature with a very short holding time. The powder loaded into a carbon die is heated via direct current pulses and simultaneously submitted to an uni-axial pressure of several MPa. Full density of the sample is achieved within minutes. This process is used to study Cu and Ag metals interactions with V2O5 oxide. Syntheses of M xV2O5 phases (M = Cu, Ag) have been achieved within minutes. Thus Cu and Ag atoms penetrate microcrystals of V2O5 oxide at a high speed, shearing its crystal network and simultaneously rebuilding the crystal structures of the prototype networks beta, beta', epsilon or delta M xV2O5. To account for the formation of these phases identified by X-ray diffraction, structural mechanisms are proposed. Cu and Ag atomic diffusion parameters have been determined from energy dispersive X-ray spectroscopy (EDX) and electron micropobe analysis (EPMA) line scans. High values of diffusion coefficients have been determined. Cu atoms diffuse faster than Ag, D-Cu approximate to 4 x 10(-8) m(2)/s and D-Ag approximate to 0.5-1 x 10(-9) m(2)/s in epsilon and delta M xV2O5 phases, respectively. Their formation may also be used as a model for further investigations into the diffusion mechanisms of atoms in solids and for a better understanding of the SPS process.