The influences of low load cycles on fatigue damage in 0.15% C steel (C15E, No. 1.1141) are investigated in the very high cycle fatigue regime using ultrasonic fatigue testing equipment. Constant amplitude (CA) endurance limits at limiting lifetime of 10(9) cycles are determined in cyclic tension-compression and cyclic torsion tests. Non-propagating fatigue cracks are found in specimens subjected to cyclic torsion loading at the endurance limit. The endurance limit is considered as maximum stress amplitude where possibly initiated fatigue cracks do not propagate to failure. Two-step variable amplitude (VA) tension-compression endurance tests are performed with repeat sequences consisting of high stress amplitudes above the endurance limit and far greater number of cycles below. The measured lifetimes are compared with linear damage accumulation calculations (Miner calculations). If the high stress amplitude is more than approximately 13% above the CA endurance limit, detrimental influences of low load cycles and failures at low damage sums are found. If the high stress is less than 13% above the CA endurance limit, numerous low load cycles cause prolonged fatigue lifetimes and specimens can sustain large damage sums without failure. Two-step VA fatigue crack growth investigations show that load cycles below the threshold stress intensity accelerate crack growth, if the high stress intensity is 18% or more above the CA threshold stress intensity. In repeat sequences with high stress intensities 14% above threshold stress intensity, low load cycles decelerated and stopped fatigue crack growth. Low load cycles can reduce or prolong fatigue lifetimes of low carbon steel and one reason is the accelerated or retarded fatigue crack growth due to numerous low amplitudes, and the maximum load amplitude of a VA load sequence determines whether detrimental or beneficial effects prevail.