The Suzuki cross-coupling reactions using perfluoro-tagged palladium nanoparticles on fluorous silica gel (FSG) as catalyst, K2CO3 as base and TBAB as additive in H2O affording the corresponding biphenyls in moderate to high yields have been described. The catalyst can be recovered by simple filtration and reused several tinges with slight decrease in activity. (C) 2009 Elsevier B.V. All rights reserved.