In this work, nine tetrasubstituted derivatives [NH2, OCH3, Li, Na, Si(CH3)(3)/SiH2CH3, P(CH3)(2), Cl, F, and CN] of the spiropentadiene dication were analyzed within the framework of QTAIM. In the studied series, the electron-withdrawing substituents destabilize the ptC-containing spiropentadiene dication. On the other hand, stabilization of this dication is possible for electron-donating substituents only through sigma bonds, such as Li and Na. In all studied systems, according to QTAIM, the pi-electron system does not participate in the stabilization of the ptC atom in the spiropentadiene dication. a-electron-donating groups stabilize the spiropentadiene dication system by increasing the charge density of C-ext-ptC bonds, whereas electronwithdrawing groups remove the charge density from C-ext-ptC bonds.