We present a novel quantitative strategy for monitoring chemical bonding transformations in solids from the topology of their electronic structure. Developed in the context of the electron localization function formalism, it provides an unambiguous characterization of long-range interactions and bond formation. Charge flux between electron localization regions is found to hold the key for identifying the nature of the interaction between the chemically meaningful entities in the solid (valence shells, lone pairs, molecules, etc.). Because of the wide range of interesting properties that high pressure induces in molecular solids, we illustrate the potentialities Of our strategy to unveil controversial questions involved in the bond reorganization along the polymerization of CO2. Our study confirms that the topology of the bonding network in the pseudopolymeric phases points toward the incipient formation of the new bonds in the higher pressure polymers. This transformation is identified as a synchronic weakening of the intramolecular (C=O) double bond and the birth of a new intermolecular C-O bond controlled by the oxygen lone pairs. Overall, the relationship that this type of analysis establishes between different polymorphs of the phase diagram could be further exploited for the prediction of the coordination of high pressure phases, opening new avenues for experimental synthesis and structure indexation.