Liquid water transport in a polymer electrolyte fuel cell (PEFC) is a major issue for automotive applications. Mist flow with tiny droplets suspended in gas has been commonly assumed for channel flow while two-phase flow has been modeled in other cell components. However. experimental studies have found that two-phase flow in the channels has a profound effect on PEFC performance, stability and durability. Therefore, a complete two-phase flow model is developed in this work for PEFC including two-phase flow in both anode and cathode channels. The model is validated against experimental data of the wetted area ratio and pressure drop in the cathode side. Due to the intrusion of soft gas diffusion layer (GDL) material in the channels, flow resistance is higher in some channels than in others. The resulting flow maldistribution among PEFC channels is of great concern because non-uniform distributions of fuel and oxidizer result in non-uniform reaction rates and thus adversely affect PEFC performance and durability. The two-phase flow maldistribution among the parallel channels in an operating PEFC is explored in detail. (C) 2008 Elsevier B.V. All rights reserved.