The performance of a fuel cell is Subject to uncertainties on its operational and material parameters. Among operational parameters, temperature is one of the most influential factors. This work focuses on this parameter. A statistical analysis is developed on the output voltage of proton exchange membrane fuel cell models. The first model does not include any degradation, whereas the second one introduces a degradation rate on the cell active area. To complete the simulation work, a full factorial design is carried out and a statistical sensitivity analysis (ANOVA) is used to compute the effects and contributions of important parameters of the model on the Output voltage. (C) 2009 Elsevier B.V. All rights reserved.